By Jacqueline A. Hubbard,Devin K. Binder
Epilepsy is a devastating team of neurological problems characterised via periodic and unpredictable seizure task within the mind. there's a serious want for brand new medicines and ways given than no less than one-third of all epilepsy sufferers aren't made freed from seizures by means of latest drugs and develop into "medically refractory". a lot of epilepsy examine has excited about neuronal healing ambitions, yet present antiepileptic medicines frequently reason critical cognitive, developmental, and behavioral unwanted side effects. contemporary findings point out a serious contribution of astrocytes, star-shaped glial cells within the mind, to neuronal and community excitability and seizure task. in addition, many vital mobile and molecular alterations happen in astrocytes in epileptic tissue in either people and animal versions of epilepsy. The aim of Astrocytes and Epilepsy is to comprehensively evaluation intriguing findings linking alterations in astrocytes to sensible alterations answerable for epilepsy for the 1st time in booklet layout. those insights into astrocyte contribution to seizure susceptibility point out that astrocytes could signify a huge new healing aim within the regulate of epilepsy.
Astrocytes and Epilepsy comprises historical past explanatory textual content on astrocyte morphology and body structure, epilepsy versions and syndromes, and proof from either human tissue reviews and animal versions linking sensible adjustments in astrocytes to epilepsy. fantastically labelled diagrams are provided and appropriate figures from the literature are reproduced to clarify key findings and ideas during this speedily rising box. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators in addition to neurologists and different experts taking care of sufferers with epilepsy.
- Presents the 1st entire ebook to synthesize ancient and up to date study on astrocytes and epilepsy into one coherent volume
- Provides a superb source at the box of astrocyte biology and astrocyte-neuron interactions
- Details strength healing goals, together with chapters on hole junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation
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Astrocytes and Epilepsy by Jacqueline A. Hubbard,Devin K. Binder